Motif ID: STAT5{A,B}.p2

Z-value: 1.692


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT5Bchr17_-_37681837-0.448.7e-02Click!
STAT5Achr17_+_37693090-0.322.3e-01Click!


Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_49180171 3.755 NM_003445
NM_198089
 ZNF155

zinc finger protein 155

chr19_+_49248003 3.619 NM_013361
 ZNF223
zinc finger protein 223
chr19_+_49408523 2.572 NM_182490
 ZNF227
zinc finger protein 227
chr19_+_49361054 2.270 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
 ZNF226




zinc finger protein 226




chr19_+_49221333 2.184 NM_001129996
NM_013360
 ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222

chr9_-_114814286 1.972 NM_001101338
 ZNF883
zinc finger protein 883
chr19_+_61798434 1.813 NM_021216
 ZNF71
zinc finger protein 71
chr19_+_49290319 1.791 NM_013398
 ZNF224
zinc finger protein 224
chr5_+_150008030 1.731 SYNPO
synaptopodin
chr7_+_89870647 1.644 NM_001185072
NM_001185073
NM_012129
 CLDN12


claudin 12


chr7_+_89870707 1.631 CLDN12
claudin 12
chr19_-_49097774 1.589 LOC100505715
hypothetical LOC100505715
chr17_+_36665161 1.541 NM_030975
 KRTAP9-9
keratin associated protein 9-9
chr19_+_49309350 1.529 NM_013362
 ZNF225
zinc finger protein 225
chr4_+_86615275 1.492 NM_001025616
 ARHGAP24
Rho GTPase activating protein 24
chr18_+_54958095 1.452 NM_033280
 SEC11C
SEC11 homolog C (S. cerevisiae)
chr10_-_121345968 1.425 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr3_+_171422940 1.418 PRKCI
protein kinase C, iota
chr19_-_41849558 1.417 NM_153257
 ZNF461
zinc finger protein 461
chr15_+_88696480 1.375 NM_001004309
 ZNF774
zinc finger protein 774
chrX_+_105932536 1.363 NM_017752
NM_198881
 TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr20_-_25625173 1.342 NM_015655
 ZNF337
zinc finger protein 337
chr3_+_171422917 1.326 PRKCI
protein kinase C, iota
chr3_+_171422908 1.294 NM_002740
 PRKCI
protein kinase C, iota
chr19_+_49023283 1.281 NM_181845
 ZNF283
zinc finger protein 283
chr19_-_63018092 1.271 NM_024762
 ZNF552
zinc finger protein 552
chr8_-_101384633 1.206 NM_015435
 RNF19A
ring finger protein 19A
chr19_-_49696322 1.168 NM_013256
 ZNF180
zinc finger protein 180
chr19_-_49309102 1.131 LOC100379224
hypothetical LOC100379224
chr5_+_57914658 1.096 NM_138453
 RAB3C
RAB3C, member RAS oncogene family
chr19_+_58715988 1.084 NM_018555
 ZNF331
zinc finger protein 331
chr16_-_219339 1.080 NM_018032
NM_201412
 LUC7L

LUC7-like (S. cerevisiae)

chr19_+_49147219 1.077 NM_013359
 ZNF221
zinc finger protein 221
chr3_+_197951121 1.066 NM_002577
 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr17_-_18526296 1.060 NM_001145045
 ZNF286B
zinc finger protein 286B
chr19_+_49198916 1.060 NM_006300
 ZNF230
zinc finger protein 230
chr16_-_219111 1.052


chr15_+_20384835 1.046 NM_001102610
NM_052903
 TUBGCP5

tubulin, gamma complex associated protein 5

chr10_-_98315090 1.028 TM9SF3
transmembrane 9 superfamily member 3
chr19_-_62680703 1.017 NM_001024596
NM_001144068
 ZNF772

zinc finger protein 772

chr10_+_124903874 1.001 BUB3
budding uninhibited by benzimidazoles 3 homolog (yeast)
chr9_-_103185621 0.976 NM_001127610
 BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr14_-_19951417 0.941 NM_007110
 TEP1
telomerase-associated protein 1
chr19_-_49552638 0.935 NM_001083335
NM_013380
 ZFP112

zinc finger protein 112 homolog (mouse)

chr17_-_44847215 0.935 NM_002634
 PHB
prohibitin
chr16_+_52295545 0.929 FTO
fat mass and obesity associated
chr3_+_197951203 0.929 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr17_-_44847214 0.928 PHB
prohibitin
chr19_-_61874934 0.921 ZNF835
zinc finger protein 835
chr6_+_84626113 0.919 CYB5R4
cytochrome b5 reductase 4
chr17_+_15543771 0.908 ZNF286A
zinc finger protein 286A
chr18_-_41938196 0.905 NM_001001937
 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr6_+_84626146 0.893 CYB5R4
cytochrome b5 reductase 4
chr11_-_82675024 0.887 NM_021825
 CCDC90B
coiled-coil domain containing 90B
chr19_-_62782066 0.868 ZNF416
zinc finger protein 416
chr18_+_41938295 0.856 NM_138443
 HAUS1
HAUS augmin-like complex, subunit 1
chr19_+_39860398 0.856 NM_001012320
NM_018443
 ZNF302

zinc finger protein 302

chr14_-_76958984 0.855 NM_138791
NM_001113475
 C14orf148

chromosome 14 open reading frame 148

chr13_-_98202884 0.852 NM_005073
 SLC15A1
solute carrier family 15 (oligopeptide transporter), member 1
chr5_+_147695314 0.844 NM_001040433
 SPINK9
serine peptidase inhibitor, Kazal type 9
chr19_-_49131250 0.838 NM_003425
 ZNF45
zinc finger protein 45
chr19_+_42400908 0.792 ZNF383
zinc finger protein 383
chr7_-_132417374 0.789 CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr19_-_61596681 0.789 NM_144690
 ZNF582
zinc finger protein 582
chr19_+_42033106 0.784 NM_003419
 ZNF345
zinc finger protein 345
chr3_+_140545528 0.766 NM_020191
 MRPS22
mitochondrial ribosomal protein S22
chr12_+_132167551 0.758 ZNF140
zinc finger protein 140
chr19_+_42033564 0.754 ZNF345
zinc finger protein 345
chr19_+_49268106 0.746 NM_001037813
 ZNF284
zinc finger protein 284
chr19_+_62972861 0.745 ZNF586
zinc finger protein 586
chr6_-_27548438 0.737 NM_007149
 ZNF184
zinc finger protein 184
chrX_-_154216929 0.730 NM_001289
 CLIC2
chloride intracellular channel 2
chr18_-_45241014 0.724 NM_017653
 DYM
dymeclin
chr6_+_84626083 0.717 NM_016230
 CYB5R4
cytochrome b5 reductase 4
chr2_+_88772281 0.716 NM_144563
 RPIA
ribose 5-phosphate isomerase A
chr19_-_39859997 0.709


chr12_+_132167512 0.701 ZNF140
zinc finger protein 140
chr5_+_145297490 0.697 SH3RF2
SH3 domain containing ring finger 2
chr12_+_11694172 0.695 ETV6
ets variant 6
chr19_+_9112052 0.687 NM_001190791
NM_020933
 ZNF317

zinc finger protein 317

chr6_-_30766621 0.683 NM_007243
 NRM
nurim (nuclear envelope membrane protein)
chr7_-_93471463 0.669 NM_005868
 BET1
blocked early in transport 1 homolog (S. cerevisiae)
chr6_+_100075572 0.667 NM_001195131
 LOC100130890
hypothetical protein LOC100130890
chr11_-_123918759 0.662 NM_001005195
 OR8B12
olfactory receptor, family 8, subfamily B, member 12
chrX_-_139694248 0.658 NM_004065
 CDR1
cerebellar degeneration-related protein 1, 34kDa
chr19_-_42098758 0.657 NM_001171979
 ZNF829
zinc finger protein 829
chr11_+_36572615 0.653 NM_138787
 C11orf74
chromosome 11 open reading frame 74
chr4_+_157044296 0.648 NM_005651
 TDO2
tryptophan 2,3-dioxygenase
chr19_+_42099073 0.642 NM_198539
 ZNF568
zinc finger protein 568
chr17_+_36636404 0.642 NM_031961
 KRTAP9-2
keratin associated protein 9-2
chr1_+_40769877 0.640 ZNF684
zinc finger protein 684
chr11_-_82674546 0.639 CCDC90B
coiled-coil domain containing 90B
chr19_+_49337568 0.633 ZNF234
zinc finger protein 234
chr3_-_185218311 0.631 NM_001023587
NM_005688
 ABCC5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

chr19_-_62781883 0.628 NM_017879
 ZNF416
zinc finger protein 416
chr9_-_98656206 0.626 NM_001001662
 ZNF782
zinc finger protein 782
chr9_-_133945064 0.619 NM_004269
 CRSP8P
MED27
mediator complex subunit 27 pseudogene
mediator complex subunit 27
chr19_+_49337548 0.618 NM_001144824
NM_006630
 ZNF234

zinc finger protein 234

chr8_+_124154117 0.618 WDR67
WD repeat domain 67
chr3_-_120861959 0.614 NM_022135
 POPDC2
popeye domain containing 2
chr3_+_58459131 0.606 NM_153331
 KCTD6
potassium channel tetramerisation domain containing 6
chr19_+_62972808 0.597 NM_017652
 ZNF586
zinc finger protein 586
chr14_+_67356248 0.593 NM_002877
NM_133509
NM_133510
 RAD51L1


RAD51-like 1 (S. cerevisiae)


chr16_-_52295214 0.586 NM_001127897
NM_015272
 RPGRIP1L

RPGRIP1-like

chr19_+_49455872 0.582 NM_181756
 ZNF233
zinc finger protein 233
chr6_+_139136349 0.577 NM_015439
 CCDC28A
coiled-coil domain containing 28A
chr11_-_125278296 0.574 NM_031307
 PUS3
pseudouridylate synthase 3
chr8_+_124154079 0.568 NM_001145088
NM_145647
 WDR67

WD repeat domain 67

chr14_-_69953433 0.567 NM_018373
 SYNJ2BP
synaptojanin 2 binding protein
chr5_+_85949511 0.555 COX7C
cytochrome c oxidase subunit VIIc
chr15_+_39853982 0.548 MAPKBP1
mitogen-activated protein kinase binding protein 1
chr5_+_14493905 0.547 TRIO
triple functional domain (PTPRF interacting)
chr3_+_132228383 0.541 NM_001146003
NM_024800
NM_145910
 NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr12_+_132167057 0.540 NM_003440
 ZNF140
zinc finger protein 140
chr19_-_49500966 0.505 NM_004234
 ZNF235
zinc finger protein 235
chr5_-_178090203 0.504 NM_005649
 ZNF354A
zinc finger protein 354A
chr4_+_24987914 0.487 NM_013367
 ANAPC4
anaphase promoting complex subunit 4
chr20_+_39091026 0.486 TOP1
topoisomerase (DNA) I
chr15_+_39853923 0.477 NM_001128608
NM_014994
 MAPKBP1

mitogen-activated protein kinase binding protein 1

chr19_+_63611930 0.468 ZNF584
zinc finger protein 584
chr3_+_181802592 0.460 NM_001042601
NM_133462
 TTC14

tetratricopeptide repeat domain 14

chr1_+_93418866 0.444 CCDC18
coiled-coil domain containing 18
chr8_-_99375739 0.441 NM_024759
 NIPAL2
NIPA-like domain containing 2
chr14_-_67232172 0.440 NM_016026
 RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr5_+_178219519 0.436 NM_058230
 ZNF354B
zinc finger protein 354B
chr19_-_42098919 0.434 NM_001037232
 ZNF829
zinc finger protein 829
chr19_+_42553895 0.433 NM_032453
 ZNF527
zinc finger protein 527
chr1_-_33275015 0.429 AK2
adenylate kinase 2
chr13_+_114098045 0.423 NM_001164144
NM_001164145
NM_032436
 ZNF828


zinc finger protein 828


chr4_-_89299034 0.418 NM_004827
 ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr4_+_130236731 0.414 NM_001099783
 C4orf33
chromosome 4 open reading frame 33
chr9_-_133944877 0.411 MED27
mediator complex subunit 27
chr1_+_40769819 0.411 NM_152373
 ZNF684
zinc finger protein 684
chr17_+_15543615 0.407 NM_001130842
NM_020652
 ZNF286A

zinc finger protein 286A

chr5_+_85949518 0.406 NM_001867
 COX7C
cytochrome c oxidase subunit VIIc
chr3_+_123882355 0.392 NM_017554
 PARP14
poly (ADP-ribose) polymerase family, member 14
chr1_-_33275051 0.385 AK2
adenylate kinase 2
chr8_-_144770764 0.370 TSTA3
tissue specific transplantation antigen P35B
chr1_-_33275039 0.368 AK2
adenylate kinase 2
chr10_+_93548048 0.363 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr1_-_33275071 0.355 NM_013411
 AK2
adenylate kinase 2
chr9_-_103200697 0.345 NM_019051
 MRPL50
mitochondrial ribosomal protein L50
chr19_-_4853878 0.340 NM_001080523
 ARRDC5
arrestin domain containing 5
chr12_+_12857516 0.338 NM_016355
NM_201224
 DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

chr9_+_103200939 0.338 NM_003452
NM_197977
 ZNF189

zinc finger protein 189

chr19_-_41955493 0.337 NM_001193552
 ZNF850
zinc finger protein 850
chr1_-_246804680 0.337 NM_001001821
 OR2T34
olfactory receptor, family 2, subfamily T, member 34
chr3_+_51870684 0.322 NM_203424
 IQCF2
IQ motif containing F2
chr10_+_93548162 0.322 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr17_+_29606408 0.318 NM_002982
 CCL2
chemokine (C-C motif) ligand 2
chr20_-_18425811 0.317 NM_006606
 RBBP9
retinoblastoma binding protein 9
chr19_+_63611819 0.317 NM_173548
 ZNF584
zinc finger protein 584
chr11_+_4522993 0.316 NM_001004137
 OR52M1
olfactory receptor, family 52, subfamily M, member 1
chr12_-_44670632 0.316 NM_004719
 SCAF11
SR-related CTD-associated factor 11
chr1_-_33275057 0.314 NM_001625
 AK2
adenylate kinase 2
chr2_-_85435074 0.311 NM_017750
 RETSAT
retinol saturase (all-trans-retinol 13,14-reductase)
chr8_+_110415725 0.301 NM_001193557
NM_020189
 ENY2

enhancer of yellow 2 homolog (Drosophila)

chr17_-_77616968 0.301 NM_022156
 DUS1L
dihydrouridine synthase 1-like (S. cerevisiae)
chr20_-_42713663 0.301 ADA
adenosine deaminase
chr18_-_23019176 0.298 NM_031422
 CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr11_-_133628348 0.297 NM_001037304
NM_001037305
NM_014174
NM_199297
NM_199298
 THYN1




thymocyte nuclear protein 1




chr9_+_111582317 0.297 NM_053016
NM_007203
NM_147150
 PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr19_+_58239802 0.296 NM_001191055
 HERV-V2
envelope glycoprotein ENVV2
chr16_+_74901235 0.294 NM_138994
 CNTNAP4
contactin associated protein-like 4
chr12_-_12182641 0.291 LRP6
low density lipoprotein receptor-related protein 6
chr2_+_69974581 0.290 NM_006857
 SNRNP27
small nuclear ribonucleoprotein 27kDa (U4/U6.U5)
chr13_-_24395054 0.288 NM_018451
 CENPJ
centromere protein J
chr17_-_7083321 0.288 NM_024297
 PHF23
PHD finger protein 23
chr10_+_93548119 0.280 NM_025235
 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr19_-_63119746 0.280 NM_152475
 ZNF417
zinc finger protein 417
chr10_-_38305458 0.279 NM_145011
 ZNF25
zinc finger protein 25
chr19_+_45168872 0.279 NM_006503
NM_153001
 PSMC4

proteasome (prosome, macropain) 26S subunit, ATPase, 4

chr19_-_42777486 0.277 NM_016536
 ZNF571
zinc finger protein 571
chr11_-_33678861 0.276 NM_001166692
 C11orf91
chromosome 11 open reading frame 91
chr17_-_77616953 0.276 DUS1L
dihydrouridine synthase 1-like (S. cerevisiae)
chr1_-_158883666 0.274 NM_003037
 SLAMF1
signaling lymphocytic activation molecule family member 1
chr5_+_140733664 0.271 NM_018919
NM_032086
 PCDHGA6

protocadherin gamma subfamily A, 6

chr19_-_49644470 0.268 NM_014518
 ZNF229
zinc finger protein 229
chr3_-_132228273 0.264 NM_014065
 ASTE1
asteroid homolog 1 (Drosophila)
chr7_+_92699588 0.262 NM_017667
NM_024553
 CCDC132

coiled-coil domain containing 132

chr12_-_61832856 0.253 NM_000706
 AVPR1A
arginine vasopressin receptor 1A
chr8_+_27687821 0.252 NM_001017420
 ESCO2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr1_+_246703249 0.252 NM_001005495
 OR2T3
olfactory receptor, family 2, subfamily T, member 3
chr17_+_30938470 0.252 AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr17_+_5264195 0.251 RPAIN
RPA interacting protein
chr12_+_21175394 0.250 NM_006446
 SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr3_-_52163745 0.246 NM_001161580
NM_001161581
NM_015426
 POC1A


POC1 centriolar protein homolog A (Chlamydomonas)


chr19_-_52045890 0.245 NM_004069
NM_021575
 AP2S1

adaptor-related protein complex 2, sigma 1 subunit

chr9_-_112139908 0.244 NM_001003936
 TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr5_+_175597943 0.242 NM_198567
 C5orf25
chromosome 5 open reading frame 25
chr1_-_153379344 0.237 NM_018973
NM_153741
 DPM3

dolichyl-phosphate mannosyltransferase polypeptide 3

chr2_-_230792844 0.234 NM_004509
NM_004510
NM_080424
 SP110


SP110 nuclear body protein


chr10_-_121346464 0.233 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr17_+_30938433 0.229 AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr1_+_148020869 0.226 NM_000566
 FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr11_+_85690900 0.224 NM_016401
 C11orf73
chromosome 11 open reading frame 73
chr20_-_47963682 0.224 NM_001135773
 SPATA2
spermatogenesis associated 2
chr7_-_44579787 0.219 DDX56
DEAD (Asp-Glu-Ala-Asp) box polypeptide 56
chr2_+_48649662 0.219 NM_172311
 STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr8_-_109330116 0.218 NM_001568
 EIF3E
eukaryotic translation initiation factor 3, subunit E

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.08 6.82e-08 GO:0006355 regulation of transcription, DNA-dependent
1.97 3.56e-07 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.01 4.46e-07 GO:0051252 regulation of RNA metabolic process
1.94 5.72e-07 GO:0010556 regulation of macromolecule biosynthetic process
1.86 5.71e-06 GO:0010468 regulation of gene expression
1.83 7.40e-06 GO:0009889 regulation of biosynthetic process
1.83 9.36e-06 GO:0031326 regulation of cellular biosynthetic process
1.79 1.84e-05 GO:0051171 regulation of nitrogen compound metabolic process
1.81 2.02e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.67 5.81e-05 GO:0060255 regulation of macromolecule metabolic process
1.57 1.45e-03 GO:0080090 regulation of primary metabolic process
1.56 1.49e-03 GO:0031323 regulation of cellular metabolic process
1.47 1.29e-02 GO:0019222 regulation of metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.28 1.79e-06 GO:0043229 intracellular organelle
1.48 2.17e-06 GO:0005634 nucleus
1.28 2.19e-06 GO:0043226 organelle
1.30 5.77e-06 GO:0043231 intracellular membrane-bounded organelle
1.30 6.44e-06 GO:0043227 membrane-bounded organelle
1.18 1.22e-03 GO:0044424 intracellular part
1.16 6.66e-03 GO:0005622 intracellular
6.79 4.93e-02 GO:0005932 microtubule basal body

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.26 4.26e-13 GO:0046914 transition metal ion binding
2.36 5.66e-13 GO:0008270 zinc ion binding
2.10 4.35e-10 GO:0003677 DNA binding
1.69 4.16e-08 GO:0046872 metal ion binding
1.67 8.77e-08 GO:0043169 cation binding
1.67 1.03e-07 GO:0043167 ion binding
1.65 1.48e-05 GO:0003676 nucleic acid binding